Here is the inspiration of the one of three female deuteragonists, Felonius' third daughter and Margo and Edith youngest sister Agnes Gru that similar to the other characters.
- Bubbles (The Powerpuff Girls)
- Ducky (The Land Before Time franchise)
- Boo (Monsters, Inc.)
- Vanelope von Schweetz (Wreck-It Ralph)
- Ami Onuki (Hi Hi Puffy AmiYumi)
- Numbuh 3 (Codemame: Kids Next Door)
- Unikitty (The Lego Movie franchise)
- Smurfette (Smurf franchise)
- Leni Loud (The Loud House)
- Bao Sanniang (Romance of the Three Kingdoms/Dynasty Warriors series)
Here is the inspiration of the one of three female deuteragonists, Felonius' second daughter and Margo and Agnes' midst sister Edith Gru that similar to the other characters.
- Buttercup (The Powerpuff Girls)
- Ruffnut Thorston (DreamWorks' Dragon franchise)
- Little Audrey (Harvey Street Kids)
- Sakura Kasugano (Street Fighter series)
- Lana Loud (The Loud House)
- Phil Deville (Rugrats franchise)
- Cera (The Land Before Time franchise)
- Asuka Kazama (Tekken series)
- Lynn Loud Jr. (The Loud House)
- Ashe (Mega Man ZX series)
- Yumi Yoshimura (Hi Hi Puffy AmiYumi)
- Ash (Illumination's Sing)
- Jailbreak (The Emoji Movie)
- Parsley (High Guardian Spice)
- Videl (Dragon Ball franchise)
Here is the inspiration of the one of three female deuteragonists, Felonius' first daughter and Edith and Agnes' older sister Margo Gru that similar to the other characters.
- Jenny Foxworth (Oliver & Company)
- Shizuka Minamoto (Doraemon franchise)
- Princess Ariel (Disney's The Little Mermaid)
- Blossom (The Powerpuff Girls)
- Karen (Frosty the Snowman)
- Roll (Mega Man classic series)
- Velma Dinkely (Scooby-Doo franchise)
- Amy Rose (Sonic the Hedgehog series)
- Kim Possible (titular character)
- Sam Sparks (Cloudy with a Chance of Meatballs franchise)
- Pastel (TwinBee series)
- Sherman (Mr. Peabody and Sherman)
- Yuri Sakazaki (The King of Fighters/Art of Fighting series)
- Mavis Dracula (Hotel Transylvania franchise)
- Rosemary (High Guardian Spice)
- Vanelope von Schweetz (Wreck…
Here is the inspiration of the anti-villain-turned main protagonist Felonius Gru that similar to the other characters.
▪︎Dr. Ivo "Eggman" Robotnik (Sonic the Hedgehog series)
▪︎Ernst Stavro Blofeld (James Bond movie series)
▪︎Professor Utonium (The Powerpuff Girls)
▪︎Shrek (titular character)
▪︎Megamind (titular character)
▪︎Count Dracula (Hotel Transylvania franchise)
▪︎The Grinch (How The Grinch Stole Christmas)
- Both of them are Big Goods.
- Both of them have their lovely daughters (especially the Gru Sisters (for Gru) and the Powerpuff Girls (for the Professor).
- Six of them are lovely daughters of two male Big Goods
(especially Gru (for the Gru Sisters) and the Professor (for the
- Margo and Blossom are both brainy heroines.
- Edith and Buttercup are both tomboys.
- Agnes and Bubbles are both girly girls.
- Four of them are main antagonists in the cartoon media.